Studies of the choroid plexus and its associated epiplexus cells in the lateral ventricles of rats following an exposure to a single non-penetrative blast.

نویسندگان

  • C Kaur
  • J Singh
  • M K Lim
  • B L Ng
  • E P Yap
  • E A Ling
چکیده

The choroid plexus in rats exhibited ultrastructural changes following a non-penetrative blast. The immunophenotypic features of epiplexus cells associated with the choroid plexus epithelium were also altered. In rats killed at 1 and 7 days after the blast, the intercellular spaces between the epithelial cells were greatly widened, coupled with the massive eruption and possible extrusion of the apical cytoplasm into the ventricular lumen. Associated with these changes was the passage of some monocytes/lymphocytes across the epithelium. The incidence of such a migratory phenomenon was more frequent in rats killed 7 days after the blast. In rats killed 14 days after the blast, the ultrastructural changes of the epithelial cells became less pronounced. At 21 and 28 days after the blast, the ultrastructure of the choroid plexus was comparable to that of normal specimens. The immunoreactivity of epiplexus cells in terms of their cell number and staining intensity with the monoclonal antibodies OX-42, OX-18, OX-6 and ED1 was noticeably augmented at 7 and 14 days after the blast; this, however subsided at 21 and 28 days. It is concluded that the choroid plexus is extremely sensitive to a blast wave as manifested by its structural alterations and the vigorous expression of CR3 receptors and MHC antigens by the epiplexus cells. It is suggested that a possible immune response might have been triggered in the cerebrospinal fluid ventricular system following the blast.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

بررسی اثر کورکومین بر سطح پروتئین های AQP1 در سلول های اپیتلیالی شبکه کوروئیدی بطن‌های جانبی رت نژاد ویستار

Background : Aquaporin1 (AQP1) protoin channels that expressed in the Choroid plexuses of brain ventricles, have an important role in cerebrospinal fluid (CSF) production. Some pathophysiological conditions such as intracranial hypertension, systemic hyponatremia and hydrocephalus followed by overproduction of CSF. Studies indicated that Curcumin can inhibit ionic channels. So the aim of this s...

متن کامل

بررسی کیفی و کمی بیان پروتئین‌ آکواپورین1 در شبکه کوروئید رت نژاد سویتار

Abstract Background: Choroid plexus (CP) is a branched structure made up of a single layer of epithelial cells and blood capillaries, forming the blood-CSF-barrier. The CSF (cerebrospinal fluid) is mainly produced from the CP. Aquaporin1 (AQP1), water channels that are highly expressed on the apical side of the membrane in choroid plexus, have a major role in mediating water transport across th...

متن کامل

A critical role for pannexin-1 in activation of innate immune cells of the choroid plexus

Epiplexus cells are a population of innate immune cells in the choroid plexus of the brain ventricles. They are thought to contribute to the immune component of the blood-cerebrospinal-fluid-barrier (BCSFB). Here we have developed a novel technique for studying epiplexus cells in acutely isolated, live and intact choroid plexus. We show that epiplexus cells are potently activated by exogenous A...

متن کامل

اثر مصرف مورفین خوراکی بر تکوین سلول های اپاندیمی شبکه کروئیدی دستگاه عصبی مرکزی جنین موش

Background and purpose: Previous studies have shown that morphine consumption during pregnancy could delay placental and embryonic development or could cause abnormal function of nervous system. The present study evaluates the effect of oral morphine consumption on choroid plexus ependym cells of central nervous system development in Wistar rats. Materials and methods: Wistar rats (170-200...

متن کامل

Histological and Biochemical Alterations in the Superior Colliculus and Lateral Geniculate Nucleus of Juvenile Rats Following Prenatal Exposure to Marijuana Smoke

Prenatal exposure to marijuana has been associated with a variety of brain deficits, as Δ9-tetrahydrocannabinol (THC), its main active ingredient crosses the placenta and affects foetal brain development. Despite this effect, marijuana remains a commonly abused substance among pregnant women. In the current study, we examined the histological and biochemical changes in the superior colliculus (...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Archives of histology and cytology

دوره 59 3  شماره 

صفحات  -

تاریخ انتشار 1996